Our Cali 4M with diff lock option is on order and it will be the 1st VW with a locking diff that I will have owned.
But on all the previous vehicles I have had with diff locks (Jeep Wrangler with front, centre and rear, Land Rover Defenders and Discoveries with centre locks, Haflinger with front, centre and rear, plus various collectable military vehicles fitted with mechanical diff locks) I have always engaged and disengaged the locks at least every other month to stop the mechanisms seizing up from lack of use.
Across the range of vehicles with diff locks, I have had mechanically, electrically and vacuum activated versions.
Never had one fail in over 40 years. For sure I always avoid driving more than a few yards on tarmac with them engaged to prevent putting unnecessary strain on the transmission. And if one doesn't disengage straight away, I stop and reverse on different locks to help take the load off the locked diff.
I am a firm believer that lack of use is the biggest problem with diff locks (and low range transfer boxes come to that), so I will be adopting a policy of gently "exercising" the diff lock on our new Cali on a regular basis.
Having said the above, I'll probably be jinxed now with our Cali's diff lock!!!